Tenia tecta

The 5-HT7 receptors are also positively coupled to adenylate cyclase. Since their discovery in 1993 (229-233), they have been identified in numerous mammalian species, including human. Different splice variants have been detected in the rat compared to the human, but do not seem to differ in functional properties (234-236). Early and recent in situ hybridization studies in the guinea pig and rat have demonstrated 5-HT7 mRNAs to be most abundant in the tenia tecta and piriform cortex, hippocampus, thalamus, and hypothalamus, including the suprachiasmatic nucleus (230,237-239). 

VPPn ventral peduncular pontine nucleus 51 VRe ventral reuniens thalamic nucleus 24-33, 80, 98-101 vsc ventral spinocerebellar tract 53-77, 83-85, 96-103 VTA ventral tegmental area 40-47, 80-82, 95-98 VTg ventral tegmental nucleus 53-55, 80, 99-100 vtgx ventral tegmental decussation 40-45, 79-81, 96, 98 VTM ventral tuberomammillary nucleus 35-38, 82, 90 VTRZ visual tegmental relay zone 40-42, 80, 98 VTT ventral tenia tecta 6-8, 80-81, 98-101... 

The 5-HT, receptor is expressed in the central nervous system. Northern analysis of a variety of rat [17,18,19] and guinea pig tissues [22] revealed two mRNAs of approximatively 3.1 and 3.9 kb [17,18,19,22]. In situ hybridization experiments in the mouse and rat detected the 5-HT, mRNA in hippocampus (pyramidal cells of CA2-CA3 layers, tenia tecta and fimbria fornix), hypothalamus, thalamus, amygdaloid complex, cortex, superior colliculus and dorsal and paramedian raphe nuclei [17,18,21,19 and our unpublished data]. In peripheral tissue a low expression was detected in the stomach and ileum of the rat [19,20] and a faint signal was detected in the spleen [20]. 

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