Temazepam Itraconazole

Clinically important, potentially hazardous interactions with amlodipine, anisindione, anticoagulants, aprepitant, atorvastatin, barbiturates, benzodiazepines, butabarbital, carbamazepine, chlordiazepoxide, clarithromycin, clonazepam, dorazepate, corticosteroids, cyclosporine, dexamethasone, diazepam, dicumarol, erythromycin, ethotoin, felodipine, flurazepam, fluvastatin, fosphenytoin, isradipine, itraconazole, ketoconazole, lorazepam, lovastatin, mephenytoin, mephobarbital, midazolam, nicardipine, nifedipine, nimodipine, nisoldipine, oxazepam, pentobarbital, phenobarbital, pimozide, pravastatin, primidone, quazepam, rifampin, secobarbital, simvastatin, St John s wort, temazepam, warfarin... 

No important interaction occurs between bromazepam and fluconazole, temazepam and itraconazole, zolpidem and fluconazole and probably chlordiazepoxide and ketoconazole. 

Itraconazole 200 mg daily was given to 10 healthy subjects for 4 days, with a single 20-mg dose of temazepam on day 4. A very small increase in the temazepam AUC was seen, but the psychomotor tests carried out were unchanged. ... 

The effects of itraconazole on temazepam or zopiclone and ketoconazole on chlordiazepoxide or zolpidem are small and seem unlikely to be clinically significant in most patients. 

Ahonen J, Olkkola KT, Neuvonen PJ. Lack of effect of antimycotic itraconazole on the pharmacokinetics or pharmacodynamics of temazepam. Ther Drug Monit ( 996) 18, 124-7. 

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