Teicoplanin chemical structure

Figure 1.3 Chemical structures of glycopeptides antibiotics vancomycin (1) [1], eremomycin (2) [15a], ristocetin A (3) [15b], and teicoplanin (4) [15c],...

Fig. 7.15 Chemical structures of the glycopeptide-type antibiotics vancomycin, teicoplanin and ristocetin A. For teicoplanin the prevalent derivative (A2-2, 85%) of the teicoplanin complex is shown.

Figure 4.16 Chemical structures of the macrocyclic glycopeptide antibiotics (a) vancomycin, (b) teicoplanin, (c) avoparcin, (d) ristocetin A, that have been used as chiral selectors in CSPs for HPLC. Reproduced from Ward and Farris, J. Chromatogr. A 906 (2001), copyright (2001), with permission from Elsevier.

The selected example by Seneci et al. [51] reported the use of an IDA-DC [52] (iminoDiacetic acid based double cleavable) linker for structure determination and controlled release of pool libraries based on teicoplanin aglycone (TD) [53] and tested for their antimicrobial activities. The synthesis and the structure of the linker and the structure of teicoplanin aglycone are shown in Figure 9.15. Starting from iminodiacetic acid the linker was prepared in four trivial chemical steps (the cyclic anhydride used in step 4 was prepared in two steps from iminodiacetic acid) its structure was symmetrical with the amide arm bearing the carboxylic handle for the solid support attachment and the identical other arms bearing protected propylamine groups for the library synthesis. 

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