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Technology evolution, absorbable

Technology Evolution of Absorbable/Biodegradable Polymers as Materials... [Pg.4]

The parallel artificial membrane assay (PAMPA) was first described by Kansy et al. The assay consists in measuring the rate of transfer of compounds from a donor to an acceptor compartment that is separated by a porous filter coated with a mixture of phospholipids in dodecane. The exact nature of the membrane is not known and is unlikely to be a well-defined phospholipid bilayer. Interesting correlations between kinetics of transfer and fraction absorbed in humans were, however, observed. The technology was further improved by taking into account membrane retention and the derivation of differential equations to convert flux ratios into permeability values.The system is now available in the form of a commercial instrument (PSR evolution series, pION, Inc www.pion-inc.com). Improved correlations with GIT permeability were oteerved using different lipid compositions designed to closer mimic the nature of native membranes. ... [Pg.392]

See other pages where Technology evolution, absorbable is mentioned: [Pg.3]    [Pg.3]    [Pg.4]    [Pg.5]    [Pg.7]    [Pg.9]    [Pg.11]    [Pg.404]    [Pg.359]    [Pg.189]    [Pg.601]    [Pg.36]    [Pg.36]    [Pg.4]    [Pg.284]    [Pg.206]    [Pg.254]    [Pg.601]    [Pg.91]   


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Technology evolution

Technology evolution, absorbable biodegradable polymers

Technology evolution, absorbable polymers

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