Tazobactam beta-lactamase inhibitor

Beta-lactamase inhibitors include clavulanic acid, sulbactam and tazobactam. They are structurally related to the beta-lactam antibiotics however the antibacterial activity of these compounds is very weak or negligible. They are strong inhibitors of bacterial beta-lactamases and can protect beta-lactam antibiotics from hydrolysis by these enzymes. 

Rx amoxicillin, ampicillin, bacampicillin, carbenicillin, cloxacillin, dicloxacillin, flucloxacillin, methicillin, mezlocillin, nafcillin, oxacillin, penicillin G benzathine, penicillin G potassium, penicillin Vpotassium, piperacillin, pivampicillin, pivme-cillinam, ticarcillin Penicillin and beta-lactamase inhibitors amoxicillin/ clavulanate potassium, ampicillin/sulbactam sodium, piperacillin sodium/ tazobactam sodium, ticarcillin disodium/clavulanate potassium Chemical Class Penicillin, natural... 

Ampicillin, amoxicillin, ticarcillin, and piperacillin are also available in combination with one of several 3-lactamase inhibitors davulanic acid, sulbactam, or tazobactam. The addition of a 3-lactamase inhibitor extends the activity of these penicillins to include 3-lactamase-producing strains of S aureus as well as some 3-lactamase-producing gram-negative bacteria (see Beta-Lactamase Inhibitors). 

BETA-LACTAMASE INHIBITORS (CLAVULANIC ACID, SULBACTAM, TAZOBACTAM)... 

Piperacillin-Tazobactam (Zesyn) [Anribioric/Extended Spectrum Penicillin, Beta Lactamase Inhibitor] Uses Infxns of skin, bone, resp urinary tract, abd, sepsis Action PCN plus 3-lactamase inhibitor bactericidal i cell wall synth Dose Adults. 3.375-4.5 g IV q6h i in renal insuff Caution [B, M] Contra PCN or 3-lactam sensitivity Disp Powder for inj frozen, premix inj 3.25, 3.375, 4.5 g SE D, HA, insomnia, GI upset, serum sickness-like Rxn, pseudomembranous colitis Interactions T Effects W/ probenecid T effects OF anticoagulants, MTX i effects W/ macrolides, tetracyclines i effects OF OCPs EMS T Effects of anticoagulants monitor for signs of electrolyte disturbances and hypovolemia d/t D such as X- K+ may cause allergic Rxn in pts sensitive to PCN OD May cause N/V/D, resp difficulty, and Szs symptomatic and supportive... 

Beta-Lactamase Inhibitors (Clavulanic Acid, Sulbactam, Tazobactam)... 

Beta-Lactamase Inhibitors (clavulanic acid, sulbactam, tazobactam)... 

Resistance to beta-lactams in clinical isolates is primarily due to the hydrolysis of the antibiotic by beta-lactamases. Mutational events resulting in the modification of PBPs or cellular permeability also can lead to beta-lactam resistance. Beta-lactamase inhibitors such as tazobactam inactivate beta-lactamase. 

Ampicillin, amoxicillin, ticarcillin, and others in this group can be protected from destruction by beta-lactamases if they are administered together with beta-lactamase inhibitors such as clavulanic acid, sulbactam, or tazobactam. Such mixtures have been employed against lactamase-producing H. influenzae or coliform organisms. 

Beta-Lactamase Inhibitors Clavulanic acid, suibactam, and tazobactam are used in fixed combinations with certain hydrolyzable penicillins. They are most active against plasmid-encoded beta-lactamases such as those produced by gonococci, streptococci, E coli, and H influenzae. They are not good inhibitors of inducible chromosomal beta-lactamases formed by en-terobacter and pseudomonas. 

TEM groups. Tazobactam is beta-lactamase inhibitor that helps piperacillin work better. Recently, its combination with ceftolozane and metronidazole was found to be a safe and effective new antimicrobial combination approved for the treatment of complicated gastrointestinal and urinary-tract infection [129]. 

Enzymatic hydrolysis of the beta-lactam ring results in loss of antibacterial activity. The formation of beta-lactamases (penicillinases) by most staphylococci and many gram-negative organisms is thus a major mechanism of bacterial resistance. Inhibitors of these bacterial enzymes (eg, clavulanic acid, sulbactam, tazobactam) are sometimes used in combination with peni-... 

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