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Taxol Analogs with Modified N-Acyl and 3-Aryl Groups

Taxol Analogs with Modified N-Acyl and 3 -Aryl Groups [Pg.131]

Ojima and his colleagues have also made significant contributions in this area. Thus in addition to the 3 -(4-fluorophenyl)-10-acetyldocetaxel analogs reported in the previous section, they prepared analogs such as 3 -(4-fluorophenyl)-N-(4-fluorobenzoyl)taxol by the /3-lactam method (315). [Pg.132]

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Acyl group

Acyl group acylation

Aryl groups

Modifying group

N analog

N groups

N- -, acylation

N-Acyl

N-Aryl

N-aryl groups

N-arylation

Taxol

Taxol, analogs

Taxols