Taurine Conjugated Bile Acids and Salts

The application of FD MS to the sodium salts of 147a-c has shown [M + Na] + ions and intense doubly charged ions, which enabled identification of their molecular weights109. 

Bile acids and their conjugates have been separated and mass analyzed by a direct combination of micro HPLC and FAB MS113, allowing the introduction of the total effluent into the mass spectrometer through a fused silica capillary tubing, ending with a stainless steel frit. The liquid mobile phase was vaporized on the surface of the frit, while the solute and the glycerol matrix were left on the surface and were subjected to FAB. 

Several methods of analysis of sulfonamides of pharmaceutical interest have been developed, involving their identification by mass spectrometry114-122. 

The El mass spectra of many substituted sulfonamides of the general type p-NH2C6H4S02NHR, components of pharmaceutical preparations, have been reported114,115,121,122. In the known1 mass spectrum of sulfanilamide (151a) Cambon and 

The application of MS/MS offers the advantage of simplifying cleanup procedures. To this end, CAD MIKES was applied to the detection of sulfonamide drugs and decomposition spectra were reported from [M + H]+ ions produced under Cl (i-C4H10)119. Equation 45 summarizes the most significant pathways leading to fragment 

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