Targeted oxygen delivery

Keywords— Blood Substitutes, Liposome, Targeted Oxygen Delivery, Nitric Oxide, Transfusion Alternative. 

Sakai H, Tsuchida E (2007) Hemoglobin-vesicles fa- a transfusion alternative and targeted oxygen delivery. J Liposome Res 17 227-235. Plock JA, Tromp AE, Contaldo C, et al (2007) Hemoglobin vesicles reduce hypoxia-related inflammation in critically ischemic hamsto-flap tissue. Crit Care Med 35 899-905. 

Krafft, M.P. Riess, J.G. Weers, J.G. The design and engineering of oxygen-delivering fluorocarbon emulsions. In Sub-micronic Emulsions in Drug Targeting and Delivery Benita, S., Ed. Harwood Academic Publ. Amsterdam, 1998 235-333. 

Chang CJ, Loh Z, Shi C, Anson FC, Nocera DG (2004) Targeted proton delivery in the catalyzed reduction of oxygen to water by bimetallic pacman porphyrins. J Am Chem Soc 126(32) 10013-10020... 

Although the acid cluster plays a distinct and identifiable role in the relaxation response of the protein on the first electron transfer, electrostatic calculations indicate that the full energetic contribution is quite widely distributed, with small ionization state changes of a number of residues. On the other hand, proton delivery to the quinone head group during the second reduction step is a targeted function, with discrete termini at the quinol oxygens. 

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