Targeted imaging, of tumors

TARGETED IMAGING OF TUMORS, AND TARGETED CAVITATION THERAPY, WITH LIPID-COATED MICROBUBBLES (L.C.M.)... 

Hu, H., Xiong, L.Q., Zhou, J., etal. (2009) Multimodal-luminescence core-shell nanocomposites for targeted imaging of tumor cells. Chemistry —A European Journal, 15, 3577—3584. 

TARGETED ULTRASONIC IMAGING OF TUMORS WITH L.C.M. AS A CONTRAST AGENT... 

Figure 13.43 In vivo upconversion luminescence imaging of subcutaneous HeLa tumor-bearing athymic nude mice (right hind leg) after intravenous injection of (A) UCNPS-NH2 or (B) UCNPs-FA. All images were acquired under the same instrumental conditions (power density approximately 120 mW cm on the surface of the mouse) [129]. (Reproduced from fiiomafen a/i, 30, L.Q. Xiong ef a/., Synthesis, characterization, and in vivo targeted imaging of amine-functionalized rare-earth up-converting nanophosphors, 5592-5600, 2009, with permission from Elsevier.)...

Harada H, Kizaka-Kondoh S, Hiraoka M. Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals. Mol Imaging 2005 4 182-193. 

Na, J.H., et al. Real-time and non-invasive optical imaging of tumor-targeting glycol cbitosan nanoparticles in various tumor models. Biomaterials 32(22), 5252-5261 (2011)... 

By modifying InP/ZnS NIR QDs with RGD peptides, the in vivo targeted imaging of a tumor with high expression was achieved. " ... 

M. D. Bednarski, et al. In vivo imaging of tumor angiogenesis Studies using polymerized vesicles co-labeled with Indium and LM609 targeting alpha(v)beta(3) on endothelium. Radiology, 217(SS), 112 (2000). 

Since the first histological evidence of the high expression of somatostatin receptors in pituitary adenomas (Reubi, 1984), many other human cancers were found to overexpaess peptide receptors in vitro (Table 2). Based on these results, p>eptide receptor hgands labeled with different probes (radionuclides, magnetic and optical probes) have been started to be developed for the in vivo targeting and imaging of tumors. 

Bloch, S., Lesage, F., McIntosh, L., Gandjbakhche, A., Liang, K. and Achilefu, S. (2005). Whole-body fluorescence lifetime imaging of a tumor-targeted near-infrared molecular probe in mice. J. Biomed. Opt. 10, 054003. 

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