Target tissue mechanical properties

Form and function target tissue mechanical properties and device function as inputs for tailoring the polymer mechanical properties... 

Physicochemical factors Irrespective of its chemical structure or mechanism of action, the carcinogenic potential of a chemical compound is dependent on its physicochemical properties which determine its "bioavailability", that is, its ability to reach target tissues and cells. The most salient of these properties are ... 

Broadly speaking, biomaterials used as supporting matrix for tissue repair applications must meet two requirements mechanical and structural similarity to the target tissues, and appropriate interactions with cells [5]. Synthetic biopolymers have attracted much attention because they display mechanical properties and degradation behaviors more suitable for some applications than their natural counterparts mentioned above. However, the synthetic biopolymers have disadvantages such as hydrophobicity and poor cell affinity as well as lack of biological responses [81]. It is a simple but effective strategy to combine synthetic biopolymers with... 

Analogous to FFA, tumor necrosis factor-a (TNF-a) is a cytokine secreted by adipose tissue, which has also been implicated as a mediator of insulin resistance in skeletal muscle and the liver. Thiazolidinediones suppress the secretion of TNF-a as well as antagonize the effects of this cytokine at the cellular level in insulin target tissues [5]. Additional mechanisms of thiazolidinedione action have also been recently identified. For example, the levels of adiponectin, a recently described protein with insulin-sensitizing properties specifically secreted by adipose tissue that circulates in... 

---