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Target Safety Assessments Evaluation of Undesired Pharmacology and Therapeutic Area Considerations

2 TARGET SAFETY ASSESSMENTS EVALUATION OF UNDESIRED PHARMACOLOGY AND THERAPEUTIC AREA CONSIDERATIONS [Pg.16]

A key component of the TSA is an evaluation of the biology of the target and the effects of engaging that target, either inhibition or activation, through review of the literature and internal company expertise. Information gathered includes [Pg.16]

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Area target

Safety assessment

Safety considerations

Safety considerations and

Safety evaluation

Safety pharmacology assessments

Target assessment

Targeted therapeutics

Targeting assessment

Targets targeted therapeutics

Therapeutic Target Considerations

Therapeutic targeting

Therapeutic targets

Undesirability

Undesirable