Target population, identification

In this way, a predictive model is developed for pharmacokinetic parameters of individuals within the population. Compared with the traditional approach, there is some important additional information that can be obtained from this technique. Firstly, the factors contributing to pharmacokinetic variability in the target population can be identified and quantitated. Secondly, the eflFects of many variables can be screened, in fact as many variables as are collected on the case report form. This may enable identification of important drug interactions, or of other patient factors affecting pharmacokinetics that may not have been suspected. Thirdly, as efficacy and tolerability data have been collected in the same patients, this analysis might help to establish a range for therapeutic concentrations. 

Hazard identification consists in identifying the type and nature of adverse effects caused by the agent in the receptor (target organism, system, or (sub) population). 

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