Target-detection-error-rate

S.3.3.2 Mass Accuracy Before measuring the samples, accurate mass calibration was performed using flow injection of a 1,3,6-polytyrosine solution (m/z 181, 507, and 997) in methanol/water (50/50 v/v) with 0.1% formic acid at a flow rate of 10 pL/min. No recalibration was performed during the experiments. While for identification of unknowns the mass accmacy is of greatest importance (Hogenboom et al., 2009), this is not a strict prerequisite for target analysis, such as in this study, as the mass error could be accounted for from the injection of calibration solutions. Still, the mass accuracy should be stable over a whole analytical sequence to ensure accurate peak detection and integration. To study the mass accuracy, the drift in mass... 

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