Tang total synthesis

Trost, B. M. Tang, W. Schulte, J. L. Asymmetric synthesis of quaternary centers. Total synthesis of (-J-malyngolide. Org. Lett. 2000, 2, 4013-4015. 

Nicolaou, K.C., Koftis, T.Y, Vyskocil, S., Petrovic, G., Ling, T.T., Yamada, Y.M.A., Tang, W.J., and Frederick, M.O. 2004a. Structural revision and total synthesis of azaspiracid-1, part 2 definition of the ABCD domain and total synthesis. Angew Chem 7nf rf43(33) 4318 324. 

The total synthesis of a high affinity TSPO (translocator protein) ligands, DPA-714 (ix), starting from 3-(4-methoxyphenyl)-3-oxopropanenitrile (vii) and 2-chloro-N,N-diethylacetamide (viii) utilizing the microwave assisted organic synthesis (MAOS) has been described by Tang et al. [16]. 

In 2002, Trost and Tang reported the chiral total synthesis of (-)-codeine in short reaction steps using a palladium-catalyzed asymmetric allylic alkylation (AAA) [53] as the key transformation [54], In 2005, a detailed full account of their synthesis was published [55]. The key features of their synthesis are (1) a preparation of an aryl ether with high optical purity by the Pd-catalyzed AAA reaction, (2) the intramolecular Heck reaction to generate the A-C-E benzofuran skeleton, (3) the second intramolecular Heck reaction of Z-vinyl bromide providing the phenan-throfuran core, and (4) the intramolecular hydroamination for the construction of D-ring by the action of LDA and visible light. 

Hostettmarm K, Marston A (1995) Saponins. Cambridge University Press, Cambridge Yu BA, Sun JS (2009) Current synthesis of triterpene saponins. Chem Asian J 4 642-654 Yu B, Zhang YC, Tang PP (2007) Carbohydrate chemistry in the total synthesis of Saponins. Eur J Org Chem 5145-5161... 

K. Nicolaou, T. Koftis, S. Vyskocil, G. Petrovic, W. Tang, M. Frederick, D. Chen, Y. Li, T. Ling, and Y. Yamada, Total synthesis and structural elucidation of azaspiracid-1. Final assignment and total synthesis of the correct structure of azaspiracid-1. Journal of American Chemical Society 128 (2006) 2859-2872. 

Tang B, Bray CD, Pattenden G, Rogers J. Total synthesis of (+)-Z-deoxypukalide, a furanobutenolide-based cembranoid isolated from the pacific octocoral Leptotgorgia spp. Tetrahedron 2010 66 2492-2500. 

Snyder SA, Tang ZY, Gupta R. Enantioselective total synthesis of (—)-napyradiomycin A1 via asymmetric chlorination of an isolated olefin. J. Am. Chem. Soc. 2009 131(16) 5744-5745. 

Tang, B., Bray, C.D., and Pattenden, G. (2009) Total synthesis of (+)-intricarene using a biogenetically patterned pathway from (—)-bipirmatin J, involving a novel transaimular [5+2] (1,3-dipolar) cydoaddition. Org. Biomol. Chem., 7, 4448-4457. 

Beugelmans, R., Bois-Choussy, M., and Tang, Q., A general S,y.jl based method for total synthesis of unsymmetrically hydroxylated 2,2 -binaphthalenes, /. Org. Chem., 52, 3880,1987. 

Johnson EC, Malito E, Shen Y, Rich D, Tang WJ, Kent SB (2007) Modular total chemical synthesis of a human immunodeficiency virus type 1 protease. J Am Chem Soc 129 11480-11490... 

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