Tandem and Other Sequential Reactions Using a Hydroformylation Step

Tandem and Other Sequential Reactions Using a Hydroformylation Step 

Reactions that succeed the hydroformylation can be conducted in a separate step by using entirely different reaction conditions. Alternatively, a multi-reaction sequence can be performed in one pot by using the same reaction regime or different ones. Such transformations belong to domino reactions, multicomponent reactions, or tandem reactions. Especially in the last years, tandem reactions came in the focus of synthetic chemists. In the best case, a single catalyst mediates not only hydroformylation but also the other reactions, and we can call it auto tandem catalysis due to a suggestion by Fogg and dos Santos [2]. 

It should be noted that not only transformations that follow the hydroformylation are of particular importance in the framework of hydroformylation but also the reactions before, which means reactions that generate the olefinic substrate. The prime reaction in this connectivity is the isomerization of the olefin. 

One of the most cited reviews concerning consecutive reactions with hydroformylation at the center was published by Eilbracht and colleagues in 1999 [3]. Updates were given in 2004 and 2006 [4]. In 2013, several examples, especially concerned to natural product synthesis, were detailed in the framework of a book edited by Taddei and Mann [5], occasionally accompanied by experimental protocols. 

Hydroformylation Fundamentals, Processes, and Applications in Organic Synthesis, First Edition. 

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I 5 Tandem and Other Sequential Reactions Using a Hydroformylation Step References... 

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