Tailoring Screening to Meet Biocatalysis Challenges

There are a number of challenges to the successful development of a commercial biocatalysis process. Most of these challenges can be addressed at the outset by properly setting up a screen in order to identify a novel catalyst which has the properties necessary to carry out a reaction that can be scaled-up. The most critical challenges include the following. 

We will explore here some examples and how screens were used for developing these enzyme families, and discuss the importance of choosing the right conditions to allow for easier identification of an active enzyme that can readily be produced and scaled-up when needed. By implementing screening solutions that take these factors into account, one can exploit the vast diversity of nature s catalytic repertoire. 

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