Tacrolimus experimental model

Andoh et al developed an experimental model of tacrohmus-induced chronic nephrotoxicity through a salt-depletion maneuver in rats [549, 563]. A particular characteristic of this model is that renal functional changes and structural injury occur with tacrolimus blood levels equivalent to those found in tacrolimus treated patients, in a striking contrast with the CsA chronic nephrotoxicity model, where extremely high CsA blood levels are achieved. In this tacrohmus model there is an early and dose-dependent decrease in glom-... 

Erdogan, M., Wright, J. R., Jr. and McAlister, V. C., Liposomal tacrolimus lotion as a novel topical agent for treatment of immune-mediated skin disorders experimental studies in a murine model. Br. J. Dermatol., 146, 964—67, 2002. 

Brook NR, Waller JR, Bicknell GR, Nicholson ML. The experimental agent pirfenidone reduces pro-fibrotic gene expression in a model of tacrolimus-induced nephrotoxicity. J Surg Res 2005 125 137-143. 

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