Tablet mixing stage

Water content of the bulk tablets irrespective of the drying process was higher than at the final mix stage (Table 2). This is probably due to the compression room environment and the low initial moisture of the powder. Still, the specification limit of 2% is easily met. 

The first stage in the wet granulation process is often a dry mixing stage in which the active component is mixed with a diluent. Many drugs need to be administered in doses of only a few milligrams or even less, yet a tablet that weighs less than about 50 mg is difficult for the patient to handle conveniently. It is therefore... 

The purpose of the mixing stage is to ensure that the powder blend and hence the resulting tablets are homogeneous in content. A random mixture is defined as one where the probability of sampling a given type of particle is proportional to the number of such particles in the total mixture. Thus, the aim is to produce a... 

Figure 3 Effect of the pH of the dissolution medium on the release of mesalazine tablets tested in pH 6.5 (open symbols) and 7.0 (closed symbols) mixed phosphate buffers. The mesalazine core tablets were coated with Eudragit LlOO-55 and Eudragit SlOO combinations of 1 4 (squares), 1 5 (triangles), and 0 1 (circles) ratios (w/w) and tested in 0.1 N HCl for 120 min prior to the buffer stage. The dissolution test was performed using United States Pharmacopoeia method B for extended-release tablets. The vertical bars indicate standard errors of the means (n = 6). (Adapted from Ref. 35.)...

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