Table of organic solvents

Viscosity tq is given in mPa s at 20 °C. Solvents with a higher viscosity than water with T) = 1.0 are less suited for HPLC because the pressure drop will be high. Refractive index As the abbreviation shows, n is given at 20 °C. 

UV cutoff This is the wavelength at which the absorbance of the pure solvent is 1.0, measured in a 1 cm cell with air as the reference (10% transmittance). The values listed here are only valid for highly pure solvents. Less pure solvents have higher UV cutoffs. 

Boiling point Too low a boiling point is less convenient. There is a danger of vapour bubbles in the HPLC system. A solvent loss can occur during degassing. 

Dipole character n is a measure of the ability of the solvent to interact with a solute by dipolar and polarization forces. 

Practical High-Performance Liquid Chromatography, Fifth edition Veronika R. Meyer 

Practical High-Performance Liquid Chromatography, Fourth edition Veronika R. Meyer 2004 John Wiley Sons, Ltd ISBN 0-470-09377-3 (Hardback) 0-470-09378-1 (Paperback) 

TABLE 5.1 Eluotropic series with soivent properties 

Solvent Strength Viscosity e ° f/(mPa s) Refractive index D UV cutoff (nm) Boiling point (°C) Dipole Acidity n a Basicity P 

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