Systemic acquired resistance derivatives

The in vitro system has some limitations and it can be used only as a model to address acquired drug resistance, because cell lines may not accurately reflect the in vivo situation of patients treated with anticancer drugs. In vivo analysis using patient samples to study anti-cancer drug resistance are described in the published literature. Chang and coworkers (64) showed that the gene-expression patterns from mRNA derived from needle biopsies of breast cancer patients treated with the anticancer drug, docetaxel, could be predictive of response to the therapy. 

The absolute accuracy of our FobIS measurement system is not comparable to commercial lab equipment, and there are important variations in SNR, depending on the impedance values and frequency measured. Nonetheless, we can use it to acquire impedance data in the field with good reproducibility. These data can be used to compute features for classification, i.e. gas discrimination. As usual in multivariate classification, features are derived from the measured raw data, e.g. mean values or slopes of the impedance spectrum or the resistance response curve in TCO [20]. 

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