System suitability parameters capacity factor

Other results obtained from the ruggedness test are the definition of optimized method conditions for the factors and of system suitability criteria for a number of responses. System suitability parameters [6,17] are defined as an interval in which a response can vary for a rugged method. The system suitability criteria are the range of values between which a response (e.g. retention time, capacity factor, number of theoretical plates, resolution) can vary without affecting the quantitative results of the analysis. For instance, a design is performed and the retention time of the main substance varies between 200 s and 320 s without affecting the quantitative determination of the substances. The system suitability criteria for the retention time is then defined as the interval 200 s - 320 s. 

Additional System Suitability Parameters. Other parameters for system suitability testing can be considered (e.g., capacity factor, number of theoretical plates, etc.). 

Additional system suitability parameters Other parameters for system suitability testing can be considered (e.g., capacity factor, number of theoretical plates, etc.). Capacity factor can be especially important in methods used for stability testing, where adequate resolution of the peak of interest from the solvent front is required so that any degradation products are suitably resolved. 

System suitability should be based on criteria and parameters collected as a group that will be able to define the performance of the system. Some of the common parameters used include precision of repetitive injections (usually five or six), resolution (R), tailing factor (T), number of theoretical plates (N), and capacity factor ( ). 

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