Synthetic strategy 738 INDEX

Barone, R. Petitjean, M. Baralotto, C. Piras, P Chanon, M. Information theory description of synthetic strategies A new similarity index. 2003, 16, 9. 

Importantly, it has subsequently been shown that the Weiner index for a molecular graph may have strong correlations with chemical properties [49-51]. Consequently, it is often the objective of synthetic efforts, particularly in drug discovery optimization, to construct compounds with certain properties by synthesizing lead compounds with a particular Weiner index. This strategy is an important example of how computed properties (that correlate predictively with desired properties) can be used to create new compounds that have certain values that is, they occupy certain regions of a chemical descriptor space [44],... 

For compounds prepared in mixtures, the identification of the active compound(s) from these mixtures is approached in various ways. Methods comprise identification by analytical means, iterative or noniterative strategies, as well as the generation of indexed libraries, or elucidation of the structure by the aid of so-called "tags" that encode for the single building blocks and the synthetic history. 

CONTENTS Introduction to the Series An Editor s Foreword, Albert Padwa. Preface, Dennis P. Curran. Steiic Course and Mechanism of 1,3-Dipolar Cycloadditions, Rolf Huisgen. Nonstabilized Azomethine Ylides, Edwin Vedejs. Molecular Rearrangements Occurring from Products of Intramolecular 1,3 Dipolar Cycloadditions Synthetic and Mechanistic Aspects, Arthur G. Schultz. Dipolar Cycloadditions of Nitrones with Vinyl Ethers and Silane Derivatives, Philip DeShong, Stephen N. Lander, Jr., Joseph M. LeginusandC. Michael Dickson. The Cycloaddition Approach to b-Hydroxy Carbonyls An Emerging Alternative to the Aldol Strategy, Dennis P. Curran. Index. 

Molecular control over EHS as well as performance properties were attained through a design strategy that started with the creation of a chemical library composed of 239 potential solvent candidates. Relevant platform molecnles were selected in order to fulfil a diversity of design criteria inclnding a high renewable atom index, moderate to low vapour pressure and a cost-effective synthetic accessibility (see Table 10.4). 

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