Synthetic multiple-interaction CSP

The synthetic multiple-interaction or Pirkle-type class of CSP is not covered by patents in the same way that some other classes of CSP are. Accordingly researchers other than Pirkle s group have made Pirkle-type CSP worthy of commercialisation. Lindner has made tartramide coated phases, as well as derivatives [11], phases derived from cinchona alkaloids [12] utilising 

Just as Pirkle does not have a monopoly on synthetic multiple-interaction CSP, similarly Regis do not have a monopoly on their commercialisation. Kromasil [C6] market a range of CSP based on the work of AUenmaik s research group [15] in which a derivatised tartramide chiral network polymer is covalently bonded to silica. As discussed later, these products are geared towards the preparative chiral LC market. In this market the advantage of all synthetic multiple-interaction CSP that the retention order of enantiomeric analytes may be switched by switching from the CSP based on the R-chiral selector to that based on the S-chiral selector or vice versa is particularly pertinent. This feature will ensure that there remains a future for synthetic multiple-interaction CSP even in the face of successftil developments of CSP with a broader spectrum of enantioselectivity. 

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The current success and dominance of the commercial CSP market by derivatised polysaccharide, macrocyclic antibiotic and, to a lesser extent, synthetic multiple-interaction Pirkle-type materials is such that it could be considered questionable whether or not there is a need to maintain an awareness of the capabihties of some of the earlier developed CSP. Indeed in a rather shrewd marketing move some Diacel products have been dubbed historical CSP. This suggests, at the same time, that the newer CSP represent a major advance in technology but that the older ones are well worth preserving. The latter point is especially true. No matter how successful multi-column screening approaches... 

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