Synthetic Methods Database CHEMINFORM

Current awareness of new chemical reactions can. in principle. be organized in databases as for other types of queries, with search profiles that are automatically executed at each database update ( alerts . SDls ). Because of the frequency of updating (see Section 3.2), at present this only makes sense for CASREACT. Although the printed current awareness journals, such as the Journal of Synthetic Methods, Current Chemical Reactions, Methods in Organic Synthesis, and Cheminform RX are all available in electronic form, both as in-house databases for MDL s REACCS or ISIS system, and, with the exception of Current Chemical Reactions and Methods in... 

As quite a number of reactions are, like other chemical information, first, or only, published in patents, these are an important source of reaction information, even though one would normally assume that new synthetic methods would also be published in the journal literature. Since 1991, reactions taken from patents have been included in CASREACT patents comprise less than 10% of the CASREACT database in 1997, compared to about 16% of the CA database. CrossFire plus Reactions contains many reactions from patents registered before 1980, when Beilstein ceased to index patents. About 14% of the reactions in CRDS/JSM and 10% of those in ChemReact originate from patents CCR includes only US patents, which contribute about 10% of the reactions and Cheminform covers no patents at all. 

MDL provides several collections of novel syntheses and preparative methods in organic chemistry (from 1946) with varying selection criteria. Database offerings include the Cheminform Reaction Library (Cheminform RXL) Comprehensive Heterocyclic Chemistry (CHC) Current Synthetic Methodology (CSM) REACCS-JSM ORGSYN and Solid-Phase Organic Reactions (SPORE). 

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