Synthetic medicinal compounds, oxazoles

Oxazoles are known in natural products and also find wide incorporation into synthetic medicinal compounds. Oxazoles can be found in the natural products (-)-hennoxazole A (antiviral) and leucascandrolide A (cytotoxic and antifungal). Benzoxazoles and isoxazoles are less common in natural products. Pseudo-pteroxazole (benzoxazole-containing anti-tubercular agent) and ibotenic acid (isoxazole-containing neurotoxin) are two examples. 

Monocyclic and Bicyclic aromatic heterocycles such as imidazoles, thiazoles, thiadiazoles, oxazoles, oxadiazoles quinazolines, indoles, benzimidazoles, purines pyrido[43-d]pyri-midines, thiazolo[5,4-d]pyrimidines, thiazolo[4,5-d]pyrimidines, oxazolo[5,4-d]pyrimi-dines and thieno[2,3-d]pyrimidines are renowned pharmacophores in drug discovery. These special structures are well explained and exemplified in chemical compound libraries. In this chapter, several types of thiazole based heterocyclic scaffolds such as mono-cyclic or bicyclic systems synthesis and their biological activities studies are presented, which are not frequently present in books and reviews. We mention the first importance of synthetic route of various thiazole based compounds and their applications in medicinal chemistry in this chapter. 

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