Chemical compound libraries

Some of the common steps toward preparing and filtering chemical compound libraries include... 

Most corporate databases of chemical compounds (libraries) are of the 2D type. The databases are managed using software that allows fast registration of new structures, fast retrieval of previously stored compounds, and fast substructure searching. (For more information about chemical database management software, see www.mdl.com or www.daylight.com.)... 

Because of its homogeneous format, AlphaScreen can be easily miniaturized, making it suitable for screening chemical compound libraries. However, special cautions have to be taken in handling the donor beads because of the sensitivity of the photosensitizer to ambient light. 

LeadQuest Chemical Compound Libraries (2000), Tripos Inc., St. Louis, MO. 

In addition to natural product sources, chemical compound libraries are used frequently in the drug discovery process. These libraries can range from small, focused libraries specifically synthesized with a particular target in mind to massive, randomly generated libraries. While there is still the problem of deconvolution of an active library, synthetically generated libraries do have a few advantages over natural product extract mixtures. There are typically equal... 

Monocyclic and Bicyclic aromatic heterocycles such as imidazoles, thiazoles, thiadiazoles, oxazoles, oxadiazoles quinazolines, indoles, benzimidazoles, purines pyrido[43-d]pyri-midines, thiazolo[5,4-d]pyrimidines, thiazolo[4,5-d]pyrimidines, oxazolo[5,4-d]pyrimi-dines and thieno[2,3-d]pyrimidines are renowned pharmacophores in drug discovery. These special structures are well explained and exemplified in chemical compound libraries. In this chapter, several types of thiazole based heterocyclic scaffolds such as mono-cyclic or bicyclic systems synthesis and their biological activities studies are presented, which are not frequently present in books and reviews. We mention the first importance of synthetic route of various thiazole based compounds and their applications in medicinal chemistry in this chapter. 

K.-H. Park, J. Ehrler, H. Spoerii, M. J. Kurth, Preparation of a 990-member chemical compound library of hydantoin- and isoxazohne-containing heterocycles using multipin technology. J. Comb. Chem. 2001, 3, 171-176. 

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