Synthetic glycoconjugates

S. D. Gamage, A. A. Weiss, and S. S. Iyer, Differentiation between structurally homologous Shiga 1 and Shiga 2 toxins by using synthetic glycoconjugates, Angew. Chem. Int. Ed., 47 (2008) 1265-1268. 

Jennings HJ, Sood RK (1994) Synthetic glycoconjugates as human vaccines. In Lee YC, Lee RT (eds) Neoglycoconjugates preparation and applications. Academic Press, San Diego, p 325... 

Anti-Lex and anti-Ley antibodies have been detected in the sera of H. pylori-infected patients, particularly those with prolonged infection, using H. pylori LPS (Appelmelk et al., 1996 Heneghan et al., 2001 Hynes et al., 2005). Importantly, the use of synthetic glycoconjugates in solution or on a solid phase does not optimally... 

Porro M, Costantino P, Viti S, Vannozzi F, Naggi A, Torri G. 41. Specific antibodies to diphtheria toxin and type 6A pneumococcal capsular polysaccharide induced by a model of semi-synthetic glycoconjugate antigen. Mol. Immunol. 1985 22 907-919. 

In addition, carbohydrate conjugates can be utilized to develop carbohydrate-based vaccines for treatment of diseases in which carbohydrate toxins or antigens, respectively, are involved. Thus, fully synthetic glycoconjugates might be developed into vaccines for malaria, and other parasites such as different bacteria, tuberculosis, tropical diseases, leishmaniasis and the Influenzae virus. 

Three-component fully synthetic glycoconjugate vaccines... 

Synthetic glycoconjugates related to methionine- and leucine-enkephalins, with different sugar-peptide linkages (ester, amide, ether) and sugar position, type and substituents were examined by reversed-phase h.p.l.c. with CF3CO2H as an ion-pair reagent. ... 

Anti-carbohydrate antibodies to synthetic glycoconjugates have been elicited in rabbits. A radio-immunoassay procedure was developed to define the specificities of the antibodies towards different carbohydrates. 

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