Synthesis on polymer support

Olefin formation, by reductive elimination of 3-hydroxysulfones, 72, 2 Olefins, hydroformylation of, 56, 1 Oligomerization of 1,3-dienes, 19, 2 Oligosaccharide synthesis on polymer support, 68, 2 Oppenauer oxidation, 6, 5 Organoboranes ... 

Scheme 15.52. One-pot procedure for tetrazole synthesis on polymer support.

This chapter discusses recent examples of enzymic oligosaccharide synthesis on polymer supports. Examples include cases where water insoluble acceptor-polymers of improved accessibility are used with soluble enzymes, and cases where water-soluble acceptor-polymers are used with either insoluble or soluble enzymes. The methodology is useful for preparative-scale reactions and for the study of enzymic properties. 

The method was also used to follow Dieckmann cyclization of a resin-bound pimelate ester. In loading of the resin and the subsequent reactions, scintillation counting was used to determine the fate of the radiolabel (Crowley and Rapoport, 1970). In oligonucleotide synthesis on polymer supports, thymidine [( H)methyl] was loaded on the polymer. This aided in determination of molar ratio of the products after cleavage, by a combination of scintillation counting and uv spectrophotometry (Narang et aL, 1977). 

V. Strategies Used for Oligonucleotide Synthesis on Polymer Supports... 

V. STRATEGIES USED FOR OLIGONUCLEOTIDE SYNTHESIS ON POLYMER SUPPORTS... 

Like any other solid-phase methods of synthesis, oligonucleotide synthesis on polymer supports offers the advantages of ease and quickness of product isolation. Because the synthesis is a sequential type, the successive coupling operations can be done on intermediates still bound to the polymer. The method appears to be attractive for the synthesis of short... 

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