Synthesis of Tetrahydro-beta-carbolines Type III

On the basis of the successful application of intramolecular tandem Pictet-Spengler cyclization of active V-acyliminium intermediates to construct small molecules library embedded with diaza-bridged heterocycles in Section 5.2.1.1, we also developed a solid- 

DIVERSITY-ORIENTED SYNTHESIS OF PRIVILEGED HETEROCYCLES USING DIVERGENT STRATEGY 

2 Practical Solid-Phase Synthesis of A -2-Oxopiperazines via /V-Acyliminium Ion Cyclization (Type IV) 

Although A -2-oxopiperazine core skeleton is well known as a remarkable pharmacophore, there are few examples of reported synthetic methods aiming at practical construction of a A -2-oxopiperazine library in the solid phase Therefore, to overcome limitation of the library construction, we developed a practical procedure for efficient synthesis of a pilot library embedded with privileged A -2-oxopiperazine core skeleton through sohd-phase parallel synthesis. 

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