Synthesis of Pyrroles via 2 2 1 Cycloaddition Reactions

Other harder nudeophiles, such as amides and amines, were inefficient in this transformation. 

Arcadi et al. reported that 1,2,3,5-tetrasubstituted acyl- and carbethoxypyrroles 287, possessing various functional groups, could be synthesized from homopropargylic 

Dake extended this approach to the synthesis of pyrroles 293 from monocarbonyl-containing skipped propargylic ketones 290 catalyzed by Ag- or Au(I)-triflates 

A recent report from Kirsch s group illustrated that vinyl propargyl ethers 36, as surrogates of skipped allenyl ketones 37, could be employed in a very efficient synthesis of densely substituted pyrroles 29S via the Ag/Au(I)-catalyzed 

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