Synthesis of PAEs Utilizing a Combinatorial Approach Caveat Emptor

Synthesis of PAEs Utilizing a Combinatorial Approach Caveat Emptor 

Lavastre s approach is valid, but the use of (a) less reactive brominated arenes and (b) the obvious lack of solubilizing groups restricts the value of this approach. Perhaps all of the 96 polymers would have to be made in a conventional approach and compared to the polymers obtained by the high-through-put method to draw further conclusions. In addition, the fluorescence was measured in situ, in a THF/diisopropylamine mixture in the presence of the Pd-Cu catalyst. That approach may have an intrinsic problem too, because it is known that PAEs are solvatochromic, and as a consequence, the obtained fluorescence data might be biased. However, with some tweaking this is a powerful method to obtain a cornucopia of different structures quickly and without too much synthetic effort, if the monomers are easily available. 

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