Synthesis of p-Hydroxy Esters Using Active Manganese

The following is a representative procedure to a slurry of Rieke manganese 

The resulting mixture was stirred at rt for 30 min. The reaction mixture was quenched with 3M HCl (10 ml) and extracted with ether (2x 10 ml), and the combined organic layers were sequentially washed with saturated NaHCOs, Na2S20s, and NaCl solutions, dried over MgS04, and concentrated. Flash chromatography (ethyl acetate-hexanes) afforded ethyl 4-(3-bromo-4-thienyl) benzoate in 70% isolated yield. 

6 Synthesis of p-Hydroxy Esters Using Active Manganese 

The active manganese was prepared following the procedure presented in the preceding text [68, 69]. The basic procedure involves the reduction of an anhydrous manganese salt with lithium and naphthalene in THF under an argon atmosphere at it. 

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Synthesis of p-Hydroxy Esters Using Active Manganese 345 Table 8.21 Reactions of a-bromoester with carbonyl compound using Mn. ... 

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