Synthesis multicomponent reactions

Keywords Fluorous chemistry Microwave synthesis Solid-phase extraction High-throughput synthesis Multicomponent reaction... 

Keywords Complexity Diversity oriented synthesis Multicomponent reactions Scaffold diversity Synthesis... 

Keywords Strecker reaction, a-aminonitriles, carbonyl compounds, TMSCN, Zr0Cl2.8H20, homogeneous catalyst, one-pot synthesis, multicomponent reaction (MCR), solvent-free, room temperature... 

A new multicomponent reaction of nitro compounds with isocyanides gives ct-oxyimi-noamides, which are important for dnig synthesis such as cephiilosporin and fi-lactamase inhibitor fEq 6 65 Multicomponent reactions using isocyanides fUgi reacdoni is re-... 

Microwave-Assisted Multicomponent Reactions for the Synthesis of Heterocycles... 

Keywords Heterocycles Multicomponent reactions Microwave Organic synthesis... 

Bagley MC, Lubinu MC (2006) Microwave-Assisted Multicomponent Reactions for the Synthesis of Heterocycles. 1 31-58... 

Mitchell, M. C., Spikmans, V., Bessoth, F., Manz, a., de Mello, A., Towards organic synthesis in microfluidic devices multicomponent reactions for the construction of compound libraries, in van den Berg, A., Olthuis, W., Bergveld,... 

Lombardo, M. Trombini, C. (1998) One-Pot Multicomponent Reactions. In Seminars in Organic Synthesis XXIII Summer School A. Corbella , pp. 7-32. Societa Chimica Italiana, MUan. 

Dondoni, A. Massi, A. (2006) Design and Synthesis of New Classes of Heterocyclic C-Glycoconjugates and Carbon-Linked Sugar and Heterocyclic Amino Acids by Asymmetric Multicomponent Reactions (AMCRs). Accounts of Chemical Research, 39, 451M63. 

Another kind of combinatorial synthesis can be applied to reactions that assemble the product from several components in a single step, a multicomponent reaction. A particularly interesting four-component reaction is the Ugi reaction, which generates dipeptides from an isocyanide, an aldehyde, an amine, and a carboxylic acid. 

In this context it must be mentioned that the procedure by Kennedy and coworkers, in which a novel resin-bound isonitrile is applied in an Ugi multicomponent reaction for the synthesis of 2,5-diketopiperazines and 1,4-benzodiazepine-2,5-diones, was discussed earlier, in Chapter 9. 

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