Synthesis metal azide hydrazines

Pyrrolo[3,2-df pyridazines are a class of interesting and useful A -heterocycles [40—42]. However, synthetic methods for such heterocyclic compounds have been very much limited such as condensation of pyrrole-2,3-diones with hydrazine. There are no reports on one-pot multi-component synthesis of pyrrolo[3,2-(f py-ridazines [43]. Moreover, synthetic methods for pyrrole-2,3-diones are also very limited [43]. On the other hand, transition-metal-mediated reactions of azides are of great importance and versatility in organic synthesis, because azides could be readily transformed into a wide variety of valuable A -containing natural products and medicinal agents [44-50]. 

Transition metal hydrazine perchlorate, nitrate, and azide complexes are explosive in nature, as indicated by DTA experiments and impact sensitivity measurements. Special precautions have to be taken during the synthesis and characterization of these materials. Small quantities of up to 1 g can be prepared without any explosion. Special mention should be made of the nickel hydrazine azide complex, which is prepared from NiCli + NaNa-I-2N2H4 H2O. The product is highly friction sensitive, especially in dry state, and so samples are to be handled with a Teflon spatula. A few milligrams are used for DTA and impact sensitivity tests. 

Patil, K.C., Nesamani, C., and Pai Verneker, V.R. (1982) Synthesis and characterization of metal hydrazine nitrate, azide and perchlorate complexes. Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 12, 383-395. 

Metal hydrazine complexes of azide and nitrate have been investigated as initiators. For example, the synthesis of nickel nitrate hydrazine [Ni (N03)2(N2H4)2] described in Chapter 3 has been commercially developed for use as detonators (blasting caps) in China. 

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