Synthesis ketones 5, 523 suppl

Papaveraldine. (6,7 Dimethoxy l isoquinolinyl) 13,4-dimeihoxyphenyl)meihanone 6,7-dimethoxy-l-isoquin-olyl 3,4-dimethoxyphenyt ketone 6,7-dimethoxy-l -veratro-ylisoquinoline xanthaline. CwH NOd mol wt 353.36. C 67.98%, H 5.42%, N 3.96%, O 22.64%. The old name pa-paveraldine is retained to avoid confusion. Prom opium whether papaveraldine occurs as such in the poppy plant, or h formed during the process of extraction, has not been investigated. Oxidation of papaverine to papaveraldine by SeOj Menon, Proc. Indian Acad. Sci. 19A, 21 (1944), For older references see Small, Luca, Chemistry of the Opium Alkaloids, V.S. Public Health Reports. Suppl. No. 103, Washington (1932). Synthesis from Reissert cotnpds Popp, McEwen, J Am. Chem. Soc. 79, 3773 (1957). 

O-acylation in peptide synthesis 18, 435 suppl. 26 O-acyl group migration 13,255 suppl. 26 allyl rearrangement 27, 578 coupling of halides 11, 731 suppl. 27 epimerization during oxidation 16, 319 suppl. 26 N-quaternization s. under N-Quaternization radical addition 27, 600 reduction of ketones in Grignard syntheses 19, 46 suppl. 26 ring closure, intramolecular 27, 799... 

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