Synthesis Campbell

Subsequently, alternative methods were developed by Stjernlbf and co-workers for introducing the acyl moiety and different sidechains in the ketone intermediate 14 (Lindgren et al. 1987 Stjemlof et al. 1989 Ferguson et al. 1995), which was achieved using the Campbell synthesis (Campbell et al. 1979). The resolution of 14 was performed by traditional diastereomeric crystallisation of its (+)- and ( )-dibenzoyltartaric acid salts from ethanol (Stjemlof et al. 1989). This allowed the syntheses of both ( )- and (+)-anatoxin-a in 96% ee, respectively, as they could prove later in a different conversion of 14 into anatoxin-a (Ferguson et al. 1995). 

HOCH CAMPBELL Azindtna Synthesis Azindines from oximes or from a haioimines (via azinnes)... 

The Hoch-Campbell aziridine synthesis entails treatment of ketoximes with excess Grignard reagents and subsequent hydrolysis of the organometallic complex. ... 

An intramolecular trapping variant of the Hoch-Campbell aziridine synthesis was reported by Taguchi et When 2-(l-p-chlorophenylcyclohexyl)cyclohexanone (16)... 

Rosolowsky, M. and Campbell, W. B., Synthesis of hydroxyeicosatetraenoic (HETES) and epoxyeicosatrienoic acids (EETS) by cultured bovine coronary artery endothelial cells, Biochim. Biophys. Acta, 1299, 267, 1996. 

Adams SR, Campbell RE, Gross LA et al (2002) New Biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo synthesis and biological applications. J Am Chem Soc 124 6063-6076... 

Murthy N, Campbell J, Fausto N, Hoffman AS, Stayton PS (2003) Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides. J Control Release 89 365-374... 

A. Campbell, Abstracts of Papers, 6th CHI High-Throughput Organic Synthesis Meeting, San Diego, CA, 2001, Poster 8. Y.-D. Gong, H.-Y. Sohn, M. J. Kurth,... 

Campbell, M.M. and Carruthers, N., Synthesis of a-aminophosphonic and a-aminophosphinic acids and derived dipeptides from 4-acetoxyazetidin-2-ones, Chem. Commun., 730, 1980. 

Campbell and coworkers287,297 also published work on methanol synthesis. In that case, they also found that the active site is metallic copper, but they suggest that the mechanism in that case does involve formate intermediates, and that the ratedetermining step is likely the hydrogenation of the formate species to methanol. 

JS McMurray, DR Colman IV, W Wang, ML Campbell. The synthesis of phosphopeptides. Biopolymers (Pept Sci) 60, 3-31, 2001. 

J. N. Jacob, V. E. Shashoua, A. Campbell, R. J. Baldessarini, y-Aminobutyric Acid Esters. 2. Synthesis, Brain Uptake, and Pharmacological Properties of Lipid Esters of y-Aminobutyric Acid , J. Med. Chem. 1985, 28, 106- 110. 

Campbell, D. S. and Holt, C. E. Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation. Neuron 2001, 32, 1013-1026. 

Szardenings AK, Burkoth TS, Lu HH, Tien DW, Campbell DA (1997) A simple procedure for the solid phase synthesis of diketopiperazine and diketomorpholine derivatives. Tetrahedron 53 6573-6593... 

Hobson McCluskey J. Chem. Soc. C 1967, 2015. For a review, see Cooley Evain Synthesis 1989, 1-7. Olofson Martz Send, Piteau Malfroot J. Org. Chem. 1984, 49, 2081 Olofson Abbott J. Org. Chem. 1984, 49, 2795. See also Campbell Pilipauskas Khanna Rhodes Tetrahedron Lett. 1987, 28, 2331. 

L1 I. ynd Zweitel Synthesis 1974, 658 Matsushita Negishi J. Am. Chem. Sue. 1981, 103, 2882. J. Chem Soc., Chem. Commun. 1982, 160. For similar reactions with other metals, see Larock Bernhardt Driggs J. Organomet. Chem. 1978, IS6, 45 Yoshida Tamao Takahashi-. Kannada Tetrahedron Lett. 1978, 2161 Brown Campbell J. Org. Chem. 1980, 45, 550 Baeckslrom Bjorkling Hdgberg Norin Acta Chem. Scand., Ser. B 1984, 38. 779. 

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