Synthesis and Further Analysis

Further syntheses of [4",5"- H2]- and [4",5"- H2]-A -THC and -A -THC have been described (c/. Vol. 7, p. 50), and Crombie et al. have extended miniaturized synthesis and chromatographic analysis (c/. Vol. 6, p. 49) to cannabinoid esters,large-scale syntheses of which using acid-catalysed terpenylation of methyl olivetolate have also been described ester cleavage, using lithium n-... 

The inability of C-terminal proline to be derivatized to a thiohydantoin has been a major impediment to the development of a routine method for the C-terminal sequence analysis of proteins and peptides. Since the method was first described in 1926 (2), the derivatization of C-terminal proline has been problematic. While over the years a few investigators have reported the derivatization of proline, either with the free amino acid or on a peptide, to a thiohydantoin (6-8), others have been unable to obtain any experimental evidence for the formation of a thiohydantoin derivative of proline (9-12). Recently, utilizing a procedure similar to that described by Kubo et al. (6), Inglis et al. (13) have described the successful synthesis of thiohydantoin proline from N-acetylproline. This was done by the one-step reaction of acetic anhydride, acetic acid, trifluoroacetic acid, and ammonium thiocyanate with N-acetyl proline. We have reproduced this synthesis and further developed it to a large scale synthesis of TH-Proline. 

Potential fusion appHcations other than electricity production have received some study. For example, radiation and high temperature heat from a fusion reactor could be used to produce hydrogen by the electrolysis or radiolysis of water, which could be employed in the synthesis of portable chemical fuels for transportation or industrial use. The transmutation of radioactive actinide wastes from fission reactors may also be feasible. This idea would utilize the neutrons from a fusion reactor to convert hazardous isotopes into more benign and easier-to-handle species. The practicaUty of these concepts requires further analysis. 

The synthesis and characterization of [Ir(S2P(Me2-C6H3-2,4)2)3] and [Ir(S2CNMeR)3], R = cyclohexyl, are reported.265,266 Further tris dithiocarbamate (146) Ir111 complexes have been prepared and characterized by UV-vis spectroscopy.267 The complex [Ircp (l,2-CgFI4S2-S,S )] has been prepared and characterized by X-ray structural analysis.26... 

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