Synthesis alcohols, tert, from ketones

Trialky lalanes Stereospecific synthesis of tert. alcohols from ketones Steric effect of solvents... 

Mixed C4 olefins (primarily iC4) are isolated from a mixed C olefin and paraffin stream. Two different liquid adsorption high-purity C olefin processes exist the C4 Olex process for producing isobutylene (iCf ) and the Sorbutene process for producing butene-1. Isobutylene has been used in alcohol synthesis and the production of methyl tert-butyl ether (MTBE) and isooctane, both of which improve octane of gasoHne. Commercial 1-butene is used in the manufacture of both hnear low-density polyethylene (LLDPE) and high-density polyethylene (HDPE)., polypropylene, polybutene, butylene oxide and the C4 solvents secondary butyl alcohol (SBA) and methyl ethyl ketone (MEK). While the C4 Olex process has been commercially demonstrated, the Sorbutene process has only been demonstrated on a pilot scale. 

Synthesis of unsymmetrical sec- and tert-alcohols. An attractive route to these alcohols involves a one-pot acylation (13,210) of RMnBr followed by reaction with an alkyllithium (14, 229). The overall yield is generally higher than that obtained by reaction of the alkyllithium with the isolated, intermediate ketone. An example is the synthesis of a-bisabolol (2) from the homoallylic manganese bromide 1. These RMnBr reagents can be prepared from RLi using MnBr2, which... 

A facile, efficient and selective solvent-free synthesis of ketones from secondary alcohols with tert-butylhydroperoxide (TBHP) as the oxidant under microwave irradiation has been achieved, where the copper (II) 2,4-alkoxy-l,3,5-triazapenta-dienato complexes (CATAPD) worked as efficient catalysts providing high yields (even upto 100%) (Figiel et al, 2010). 

---