Synaptic transmission ligands

Of the several classes of receptors for endogenous chemical signals [3], two are used as postsynaptic receptors in synaptic transmission ligand-gated ion channels (LGICs) and G protein-coupled receptors (GPCRs Fig. 1). Due to the large number of transmitters and the existence of several receptor types for almost all, postsynaptic receptor activation is the most diversified step of synaptic transmission. Table 1 shows selected neurotransmitter receptors. 

Synaptic Transmission. Figure 1 Synaptic transmission. The presynaptic terminal contains voltage-dependent Na Superscript and Ca2+ channels, vesicles with a vesicular neurotransmitter transporter VNT, a plasmalemmal neurotransmitter transporter PNT, and a presynaptic G protein-coupled receptor GPCR with its G protein and its effector E the inset also shows the vesicular H+ pump. The postsynaptic cell contains two ligand-gated ion channels LGIC, one for Na+ and K+ and one for Cl-, a postsynaptic GPRC, and a PNT. In this synapse, released transmitter is inactivated by uptake into cells. 

Cyclic AMP can be viewed as subserving two major functions in the nervous system. First, cAMP mediates some short-term aspects of synaptic transmission some rapid actions of certain neurotransmitters on ion channels that do not involve ligand-gated channels are mediated through cAMP. 

Synaptic Transmission Is Mediated by Ligand-Gated Ion Channels... 

Synaptic transmission between excitable cells is mediated by ligand-gated ion channels. The presynaptic... 

---