Symptomatic liver injury

Hautekeete ML, Colle I, van Vlierberghe H, Elewaut A. Symptomatic liver injury probably related to sertraline. Gastroenterol Clin Biol 1998 22(3) 364—5. 

NAG, w/ or w/in 2 wk of D/C an MAOI Di p Caps SE t BP, tach, wt loss, sexual dysfxn EMS Use caution w/ albuterol can t CV effects monitor for liver injury (RUQ pain, h atomegaly, jaundice) t risk of suicidal thoughts OD Reports limited but may cause xCTostomia (dry mouth), anxiety, prolonged QT interval and Szs symptomatic and supportive... 

Of three patients, two women aged 62 and 57 and a man aged 75 years, who developed symptomatic hepatic injury 5-6 weeks after starting to take itraconazole, two had the biochemical pattern of cholestatic liver damage (38). 

Pulmonary edema, renal failure, and liver injury should be managed symptomatically. However, based on toxicity similarities to trichloroethylene, data on plasma levels of following 1,2-dichloroeth-ylene overdose/exposure are not clinically very useful. Renal and liver function tests should be monitored in the presence of suspected kidney or liver injury. 

Combinations of poor dietary supply, intestinal malabsorption because of the antagonistic effects of other trace elements, or blockage of uptake by substances Uke phytate — together with increased excretory losses as a result of disease, injury, and infection—can result in overt, symptomatic trace element deficiency disease. Liver disease, inflammatory bowel disease, and renal disease will affect trace element absorption and excretion to a variable extent and may cause an acquired deficiency disease. 

Vitamin E is found in the diet in the lipid fractions of some vegetable oils and in liver, egg yolks, and cereals. It is absorbed together with lipids, and fat malabsorption results in symptomatic deficiencies. Vitamin E circulates in the blood in lipoprotein particles. Its deficiency causes neurologic symptoms, probably because the polyunsaturated lipids in myelin and other membranes of the nervous system are particularly sensitive to free radical injury. 

---