Symposium on Catalysis in Organic Synthesis

Department of Chemistry, Iowa State University, Ames, Iowa 50011 

The palladium-catalyzed annulation of alkynes by functionally-substituted aryl and vinylic halides or triflates provides a veiy convenient and efficient approach to a wide variety of heterocycles and carbocycles. This chemistry has lead to the discovery of a number of novel palladium-catalyzed processes in which the palladium migrates from one carbon to another within the molecule providing a unique way to form carbon-carbon bonds in remote locations within the same molecule. 

A wide variety of heterocycles can be readily prepared by the heteroannulation of alkynes. For example, the palladium-catalyzed annulation of internal alkynes by 2-iodoanilines provides easy access to 2,3-disubstituted indoles by a process that involves initial reduction of Pd(OAc)2 to Pd(0), oxidative addition of the aryl halide to Pd(0), c/s-addition of the arylpalladium 

Similar observations have been made when employing a modification of the 

Arylpalladium intermediates bearing neighboring imine functionality have 

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The Catalytic Hydrogenation section includes the 2006 Murray Raney Award Lecture by Professor Isamu Yamauchi, Osaka University, Japan. Similarly the Novel Methods section features an invited lecture by Gadi Rothenberg, University of Amsterdam, the 2006 Paul N. Rylander Award wiimer. 2005 Rylander Award wiimer Jean-Marie Basset is also acknowledged for presenting a lecture in the symposium on Catalysis in Organic Synthesis. 

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