Sympathoadrenal lineage

Anderson, D. J. Molecular control of cell fate in the neural crest the sympathoadrenal lineage. Anna. Rev. Neurosci. 116 129-158,1993. 

Developmentally, the best characterized cell lineage within the neural crest is probably the sympathoadrenal lineage. There are three cell types in this lineage, the sympathetic neuron, the adrenal chromaffin cell and a third cell of an intermediate phenotype, the so called small, intensely fluorescent cell (SIF cell) (see Anderson, 1989 Patterson, 1990). Although progenitors of this lineage have not been isolated from neural crest cultures, they have have been isolated from embryonic adrenal medulla as well as from both embryonic and neonatal sympathetic ganglia. 

A number of other factors have been implicated in the development of the sympathoadrenal lineage and in particular the development of sympathetic neurons. IGF-1 stimulates proliferation in cultures of rat sympathetic ganglia (DiCicco-Bloom et al.,... 

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