Sympathetic system smoking

Autonomic ganglia. Ganglionic stimulation occurs in both the sympathetic and parasympathetic divisions of the autonomic nervous system. Parasympathetic activation results in increased production of gastric juice (smoking ban in peptic ulcer) and enhanced bowel motility ( laxative effect of the first morning cigarette defecation diarrhea in the novice). 

Lockett (36, 37) has described two compounds, base A and base B. Base A occurred in the urine of men (who smoked), women (who did not smoke), and bitches. There was approximately three times as much in the urine of men and bitches as of women. The base was somewhat more active pharmacologically than Z-nicotine, and was found to exert its pressor effect through the mediation of the corpus striatum and thalamus, stimulating the sympathetic nervous system (38). Base A could be converted to -nicotine by drying in a high vacuum, with alteration of its action from a central to a peripheral one therefore it must be very similar in structure to nicotine. Base B was a different compound, also with pressor activity both were obtained by steam distillation from strongly alkaline urine. Furthermore, another compound, which she called base x, appeared in the... 

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