Swern-Moffatt Oxidation Pilot Plant

Ube Industries Ltd in Yamaguchi, Japan, and Kyoto University investigated the Swern oxidation for pharmaceutical intermediates [71,73]. In this reaction, alcohols 

This microreactor system thus allows fast mixing, good temperature control, and changing process parameters at short residence times - the overall time to pass all reactors is between 8 and 11s [71,73], The timescale between end and start of a new operation is 0.01 s in order to avoid significant decomposition. Thereby, conversions and yields were determined for primary, secondary, cyclic, and benzylic alcohols in the temperature range from —20 to 20 °C, which were equal to or better than those of lower temperature batch reactions. The oxidation of cyclohexanol was run for 3 h at 20 °C and a stable process in terms of conversion and selectivity was observed. 

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