Suzuki scaffold decoration

Scheme 36 Scaffold decoration via Stille and Suzuki-Miyaura reactions on solid support...

Scheme 6.19 Scaffold decoration of heterocycles using Suzuki cross-coupling chemistry.

Recent literature examples involve the use of the Suzuki protocol for the highspeed decoration of various heterocyclic scaffolds of pharmacological or biological interest, including pyrimidines [45], pyridazines [46], pyrazines [47], chromanes [48], and pyrazoles [49] (Scheme 6.19). 

In a recent study, the group of Van der Eycken described the decoration of polymer-bound 2(lH)-pyrazinone scaffolds by performing various transition metal-catalyzed transformations [42]. The readily prepared pyrazinone was specifically decorated at the C3 position by employing microwave-mediated Suzuki, Stille, Sonogashira, and Ullmann protocols (Scheme 7.24), thereby introducing additional diver-... 

The first example of a Suzuki-Miyaura reaction on a pyridopyrimidine skeleton was used for decoration of a 4-diloro[2,3-d]pyrimidin-7(8H)one scaffold. Phe-nylboronic acid was used as a coupling partner with a good isolated yield (Scheme 15.18) [51]. 

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