Sutherlandia frutescens

Such adulteration is perilous owing to the unanticipated drag-herb interactions that may arise 43). Recently, two African medicinal plants, Hypoxis hemerocallidea (African potato) and Sutherlandia frutescens (L.) R.Br. (Fabaceae) often recommended for treatment of HIV/AIDS, showed a negative interaction with antiretroviral medication, thus patients may be at risk from treatment failure, viral resistance or drag toxicity (53). Consequently, even when these interferences do not actively cause morbidity and mortality, they can weaken the therapeutic value of concomitantly administered conventional drags... 

L-canavanine is a non-protein amino acid, an L-arginine antagonist and therefore an antimetabolite. It is found in the seeds of many legumes, being particularly high in alfalfa seeds. Lower levels are found in the South African leguminous plant Sutherlandia frutescens. 

EPS-1 Sutherlandia frutescens (syn. Lessertia frutescens) haemolysis inhibition of antibody sensitized sheep red blood cells (SRBC) in-vitro [58]... 

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