Surfactant-micellar mobile phases advantages

A practical requirement of any micellar mobile phase is its compatibility with the sample matrix. Micellar eluents can be used to dissolve samples or extract analytes. Surfactants can cosolubilize nonpolar and polar compounds, derivatization reagents and products. They can also induce favorable shifts in the equilibrium constants and spectral properties, inhibit undesirable reactions, stabilize reaction intermediates, and expedite reactions by means of micellar catalysis [4, 5]. Other potential advantages... [Pg.343]

The first report on the analytical use of an aqueous solution of a surfactant, above its critical micellar concentration (CMC), as mobile phase in reversed-phase liquid chromatography (RPLC) was published in 1980. The technique, named micellar liquid chromatography (MLC), is an interesting example of the modification of the chromatographic behavior taking advantage of secondary equilibria to vary both retention and selectivity. [Pg.808]