Surface chemical analysis, polymeric drug

Surface Chemical Analysis of Polymeric Drug Delivery Systems by Static Secondary Ion Mass Spectrometry (SSIMS) and SIMS Imaging... 

Lee, P. I. and Good, W. R., Eds. Surface chemical analysis of polymeric drug delivery systems by static secondary ion mass spectrometry (SSIMS) and SIMS imaging. In American Chemical Society Symposium Series Controlled-Release Technology, Pharmaceutical Applications. American Chemical Society, Washington, DC, 1987. 

Time-of-flight secondary ion mass spectrometry (ToF-SIMS) (Meeus et al. 2013 Scoutaris et al. 2012 Shard et al. 2009) Analysis of surface chemical composition of a sample (top 1-2 nm layer) Mapping of spatial surface distribution of mixture components, 3D chemical distribution and miscibility, relative drug distribution in multi-polymeric system Depth profiling by surface sputtering (removing dotted surface monolayers) Spatial resolution Umits the estimation of phase-separated domain... 

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