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Superlipophilic compounds

To describe the reduced bioconcentration of superlipophilic compounds, non-linear QSAR models have been derived (Table 4.15). [Pg.136]

Bioconcentration factors of dioxins in fishes are relatively low compared to other chlorinated aromatic compounds because of the low metabolic conversion of dioxins, their low available concentrations in test systems, and their highly variable uptake rates (de Voogt et al. 1990). In general, bioconcentration factors for persistent superlipophilic chemicals, such as OCDD, derived for freshwater fishes from supersaturated solutions may seriously underestimate the true BCF (Geyer... [Pg.1042]

Figure 1.4 Comparison of measured (obs.) and calculated (calc.) log values (MedChem, 1989). The agreement is generally sufficient for compounds with log < 5, whereas there are major deviations for superlipophilic chemicals. The discrepancies may be due to shortcomings in the calculation methods as well as in the reported experimental data. The major uncertainties in the measured log P values > 5 are the reason why the experimental data are not necessarily true in several cases, where the respective compounds were re-analysed, the calculated data were even better. Figure 1.4 Comparison of measured (obs.) and calculated (calc.) log values (MedChem, 1989). The agreement is generally sufficient for compounds with log < 5, whereas there are major deviations for superlipophilic chemicals. The discrepancies may be due to shortcomings in the calculation methods as well as in the reported experimental data. The major uncertainties in the measured log P values > 5 are the reason why the experimental data are not necessarily true in several cases, where the respective compounds were re-analysed, the calculated data were even better.

See other pages where Superlipophilic compounds is mentioned: [Pg.903]    [Pg.10]    [Pg.135]    [Pg.137]    [Pg.140]    [Pg.903]    [Pg.10]    [Pg.135]    [Pg.137]    [Pg.140]    [Pg.130]    [Pg.269]    [Pg.26]   
See also in sourсe #XX -- [ Pg.10 ]




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