Superfamily of Plant, Fungal, and Bacterial Peroxidases

The superfamily of plant, fungal, and bacterial heme peroxidases (also called non animal peroxidase superfamily, see Chap. 2) categorizes its components into three classes based on sequence alignment and biological origin, such as initially proposed by K.G. Welinder using the only crystal structure available at that moment (yeast CCP) as a model [3, 4]. Class III is the largest one, with over 3,000 plant peroxidase entries in PeroxiBase, followed by Classes I and II, with over 900 entries 

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Welinder KG (1992) Superfamily of plant, fungal, and bacterial peroxidases. Curr Opin Struct Biol 2 388-393... 

The peroxidase field was reviewed in depth in two volumes published in 1991 (11). Enzymes belonging to the superfamily of plant, fungal, and bacterial peroxidases were reviewed in Volume II and additionally in two other texts (12,13). General reviews on heme peroxidases since 1992 include those published by Poulos and Fenna (14) and Poulos (15), which highlight structural comparisons and potential biotechnological applications of peroxidases, respectively. One of the present authors also surveyed the heme peroxidase literature in a review published in... 

K. G. Welinder, Superfamily of Plant, Fungal and Bacterial Peroxidases. Curr. Opin. Struc. Biol., 2 (1992) 388-393. 

Peroxidases fall into two superfamilies (plant and mammalian) and a third, indistinct group that includes chloroperoxidase (a P450-like hybrid) and di-heme cytochrome c peroxidase from Pseudomonas aeruginosa. The plant peroxidase superfamily contains enzymes of plant, fungal, and bacterial origin [126], Mammalian peroxidases make up the second superfamily, and include lactoperoxidase, myeloperoxidase, and prostaglandin H synthase. Both families have been the focus of numerous excellent reviews, several of which have discussed the differences between the plant and mammalian peroxidases [126-130], Here, recent experimental investigations focused on the plant peroxidases will be discussed. 

Zamocky M (2004) Phylogenetic relationships in Class I of the superfamily of bacterial, fungal, and plant peroxidases. Eur J Biochem 271 3297-3309... 

Zamocky M, Dunand C (2006) Divergent evolutionary lines of fungal cytochrome c peroxidases belonging to the superfamily of bacterial, fungal and plant heme peroxidases. FEBS... 

Plant/fungal/bacterial peroxidases. Haem-containing peroxidases from plants, fungi and bacteria are structurally related and form a superfamily. All enzymes so far studied have mechanisms of the type illustrated in Fig. 2. They fall into three diverse classes [23,24], Class I are found in prokaryotes and some eukaryotic organelles. The best-characterised of these enzymes... 

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